Date of publication: 2017-07-08 22:45
Unlike many industry players, AbbVie has not shied away from developing new medicines to tackle the difficult research area of neuroscience. In January 7567, Abbvie announced the beginning of two Phase II clinical study programs to explore ABBV-8E67, an investigational anti-tau antibody, in patients with early Alzheimer’s disease and progressive supranuclear palsy (PSP). In recognition of the lack of treatment options available to patients with PSP, FDA granted fast track designation to ABBV-8E67. The FDA and European Medicines Agency (EMA) also granted orphan drug designations to the new drug candidate for PSP.
Lung irritants. Lung irritants are chemicals that irritate or damage pulmonary tissue. Chemical irritants are classified as primary or secondary. Primary irritants exert their effect locally, for example, acid fumes burning the lungs. Secondary irritants, such as mercury vapors, may exhibit some local irritation but the main hazard is from systemic effects resulting from absorption of the chemical.
Some metals and their compounds can be absorbed through the skin. Mercury metal, and tetraethyl lead for example can enter the bloodstream through this route. Nickel, arsenic, chromium, and beryllium cannot penetrate the skin but they can damage the skin or cause allergic-type reactions.
The potential hazards of a chemical should be known before ordering. Personnel must receive adequate training in handling the material, and plans must be made to store and dispose of the chemical properly before it is received. Chemicals should be properly labeled, inventoried, and a material safety data sheet (MSDS) should be available. Preferably, all chemicals should be received in a central location.
Planning. The procedures and risks involved should be thoroughly reviewed before working with reactive chemicals. Work should be performed with the smallest possible quantity of the chemical.
Precautionary Statements and Pictograms
Precautionary information supplements the hazard information by briefly providing measures to be taken to minimize or prevent adverse effects from physical, health or environmental hazards. First aid is included in precautionary information. The GHS label should include appropriate precautionary information. Figure - includes precautionary statements and pictograms that can be used on labels.
Cyanides. The simple metallic cyanides are highly toxic by ingestion. Cyanides are readily absorbed through the skin, mucous membranes, and by inhalation. Alkali salts are toxic by ingestion. Even small amounts of sodium and potassium cyanide are highly toxic and death may occur within minutes from ingestion. Inhalation of toxic fumes from hydrogen cyanide gas may result in death in a few seconds. Symptoms of poisoning include dizziness, headaches, tightness in the chest, palpitation of the heart, and difficulty in breathing.
Labels. In accordance with Globally Harmonized System of Classification and Labeling of Chemicals (GHS), and in compliance with OHSA labels on incoming chemicals must contain the name of the product or chemical, identify hazardous ingredents or components, display the appropriate signal word, appropriate physical, health, environmental hazard statements, supplemental information, precautionary measures & pictograms, first aid statements, and the name and address of the manufacturer. Unlabeled chemicals must not be accepted.
Metal Powders: burning time 5 and ≤ 65 minutes
Others: wetted zone stop fire for at least 9 minutes & burning time 95 seconds or burning rat /second
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Health hazard: A chemical for which there is statistically significant evidence based on at least one scientific study that acute or chronic health effects may occur in exposed individuals. Health hazards include chemicals that are carcinogens, mutagens, teratogens, corrosives, toxic and highly toxic agents, irritants, and sensitizers.